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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 84 and 434 of Plasminogen (Uniprot ID#P00747)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-34677 targets Plasminogen in ICC, IF, IHC (P), and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The PA5-34677 immunogen is recombinant fragment corresponding to a region within amino acids 84 and 434 of Plasminogen (Uniprot ID#P00747).
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
angiostatin; plasmin; plasmin heavy chain A; plasmin light chain B; plasminogen; RP1-81D8.1
Ab1-346; AI649309; Pg; PLG