This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KAASESLRMA AEILSGTPAA VQLRYLHTLQ SLSTEKPSTV VLPLPFDLLN CLSSPSNRTQ GSLPFPSPSK PVEPLNPK
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: nephrosis 2 idiopathic steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); NPHS2 podocin; PDCN; Podocin; SRN1
Gene Aliases: NPHS2; PDCN; SRN1
UniProt ID: (Human) Q9NP85
Entrez Gene ID: (Human) 7827
Molecular Function: cytoskeletal protein