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Polycystin 1 Polyclonal Antibody
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Product Details
BS-2157R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Polycystin 1, amino acids 131-230.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease 1 protein homolog; PC1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1
Gene Aliases: eliosin; mFLJ00285; PBP; Pc-1; PC1; PKD1; TRPP1
UniProt ID: (Human) P98161, (Mouse) O08852
Entrez Gene ID: (Human) 5310, (Mouse) 18763
cartilage condensation
blood vessel development
in utero embryonic development
kidney development
liver development
embryonic placenta development
protein export from nucleus
calcium ion transport
homophilic cell adhesion via plasma membrane adhesion molecules
cell-matrix adhesion
calcium-independent cell-matrix adhesion
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
heart development
anatomical structure morphogenesis
organ morphogenesis
regulation of gene expression
regulation of cell cycle process
Wnt signaling pathway
spinal cord development
neural tube development
establishment of cell polarity
regulation of cell adhesion
response to fluid shear stress
lymph vessel morphogenesis
chordate embryonic development
skin development
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
branching morphogenesis of an epithelial tube
genitalia development
detection of mechanical stimulus
cartilage development
protein heterotetramerization
regulation of cell cycle
regulation of mitotic spindle organization
lung epithelium development
placenta blood vessel development
regulation of proteasomal protein catabolic process
calcium ion transmembrane transport
nitrogen cycle metabolic process
mesonephric tubule development
mesonephric duct development
metanephric collecting duct development
metanephric ascending thin limb development
metanephric proximal tubule development
metanephric distal tubule morphogenesis
cell-cell adhesion
mitocytosis
regulation of G1/S transition of mitotic cell cycle
nitrogen compound metabolic process
cell cycle arrest
single organismal cell-cell adhesion
peptidyl-serine phosphorylation
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of protein binding
cytoplasmic sequestering of transcription factor
patterning of lymph vessels
renal system development
cation transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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