Recommended positive controls: IMR32, Neuro2A, NIH-3T3, C2C12.
Predicted reactivity: Mouse (89%), Rat (89%), Dog (88%), Pig (90%), Rabbit (91%), Sheep (90%), Rhesus Monkey (95%), Chimpanzee (98%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alternative prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; Major prion protein; MGC26679; prion-related protein; PrP; PrP27-30; PrP33-35C; TSE
AA960666; AI325101; ALTPRP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; Prn-i; Prn-p; PRNP; PRP; PrP27-30; PrP33-35C; PrP