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Invitrogen

PrP Polyclonal Antibody

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PrP Polyclonal Antibody

Product Details

PA5-79877

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human PRNP (144-160aa DYEDRYYRENMHRYPNQ).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746992

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: U87 Cell, U87 Cell.

Target Information

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alternative prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; Major prion protein; MGC26679; prion protein; prion-related protein; PRNP; PrP; PrP27-30; PrP33-35C; TSE; unnamed protein product

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Gene Aliases: ALTPRP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PRNP; PRP; PrP27-30; PrP33-35C; PrPc

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UniProt ID: (Human) P04156

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Entrez Gene ID: (Human) 5621

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Function(s)
beta-amyloid binding protease binding copper ion binding protein binding lamin binding glycosaminoglycan binding microtubule binding tubulin binding aspartic-type endopeptidase inhibitor activity type 5 metabotropic glutamate receptor binding type 8 metabotropic glutamate receptor binding signaling receptor activity identical protein binding ATP-dependent protein binding ion channel binding macromolecular complex binding metal ion binding chaperone binding binding, bridging molecular function activator activity molecular condensate scaffold activity cupric ion binding cuprous ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cellular copper ion homeostasis response to oxidative stress learning or memory long-term memory negative regulation of protein processing protein destabilization negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-2 production regulation of protein localization intracellular signal transduction negative regulation of apoptotic process positive regulation of neuron apoptotic process negative regulation of activated T cell proliferation response to cadmium ion response to copper ion positive regulation of calcium-mediated signaling negative regulation of T cell receptor signaling pathway protein homooligomerization regulation of cell cycle negative regulation of calcineurin-NFAT signaling cascade cellular response to copper ion cellular response to xenobiotic stimulus positive regulation of protein targeting to membrane dendritic spine maintenance negative regulation of long-term synaptic potentiation regulation of glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway regulation of potassium ion transmembrane transport negative regulation of beta-amyloid formation negative regulation of dendritic spine maintenance negative regulation of amyloid precursor protein catabolic process positive regulation of protein localization to plasma membrane response to amyloid-beta cellular response to beta-amyloid regulation of calcium ion import across plasma membrane neuron projection maintenance
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