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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Presenilin 1 Antibodies

          Fabgennix

          Presenilin 1 Polyclonal Antibody

          View all (29) Presenilin 1 antibodies
          Datasheet
          Protocols
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          Datasheet
          Protocols
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          Cite Presenilin 1 Polyclonal Antibody

          • Antibody Testing Data (1)
          Presenilin 1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Presenilin 1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Presenilin 1 Antibody (PSEN-112AP) in WB

          Western blot of Presenilin 1 antibody (PSEN-112AP) with rat brain. 1:500 antibody dilution in DiluOBuffer. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Presenilin 1 Antibody in Western Blot (WB)

          Product Details

          PSEN-112AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (IHC)

          1:50-1:250
          -

          ELISA (ELISA)

          1:10,000
          -

          Immunoprecipitation (IP)

          1:50-1:250
          -
          Product Specifications

          Species Reactivity

          Bovine, Cat, Human, Mouse, Non-human primate, Pig, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide taken within amino acid region 417-467 on human Presnelin-1 protein.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5-1.5 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Alzheimer Disease 3; Minilin; presenilin 1 (Alzheimer disease 3); Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

          View more View less

          Gene Aliases: AD3; Ad3h; FAD; PS-1; PS1; PSEN1; PSNL1; S182

          View more View less

          UniProt ID: (Bovine) Q9XT97, (Human) P49768, (Rat) P97887

          View more View less

          Entrez Gene ID: (Bovine) 282705, (Pig) 780411, (Human) 5663, (Rat) 29192, (Mouse) 19164

          View more View less

          Function(s)
          calcium channel activity PDZ domain binding aspartic endopeptidase activity, intramembrane cleaving endopeptidase activity aspartic-type endopeptidase activity protein binding beta-catenin binding cadherin binding peptidase activity hydrolase activity aspartic protease
          Process(es)
          autophagosome assembly negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity blood vessel development cell fate specification somitogenesis neuron migration positive regulation of receptor recycling heart looping positive regulation of L-glutamate transport hematopoietic progenitor cell differentiation astrocyte activation involved in immune response T cell activation involved in immune response protein glycosylation membrane protein ectodomain proteolysis mitochondrial transport cellular response to DNA damage stimulus response to oxidative stress negative regulation of epidermal growth factor-activated receptor activity Notch signaling pathway memory post-embryonic development regulation of neuron projection development protein transport choline transport synaptic vesicle targeting protein processing cerebral cortex cell migration Cajal-Retzius cell differentiation dorsal/ventral neural tube patterning embryonic limb morphogenesis positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis beta-amyloid formation intracellular signal transduction positive regulation of protein import into nucleus positive regulation of tumor necrosis factor biosynthetic process amyloid precursor protein metabolic process myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of catalytic activity skin morphogenesis positive regulation of glycolytic process positive regulation of transcription, DNA-templated regulation of synaptic plasticity thymus development neuron development skeletal system morphogenesis brain morphogenesis epithelial cell proliferation negative regulation of axonogenesis synapse organization positive regulation of coagulation T cell receptor signaling pathway neuron apoptotic process negative regulation of ubiquitin-protein transferase activity regulation of synaptic transmission, glutamatergic regulation of resting membrane potential regulation of canonical Wnt signaling pathway positive regulation of dendritic spine development calcium ion transmembrane transport modulation of age-related behavioral decline cell-cell adhesion cellular response to beta-amyloid negative regulation of core promoter binding positive regulation of amyloid fibril formation neuron projection maintenance negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway neural retina development Notch receptor processing L-glutamate transport single organismal cell-cell adhesion regulation of phosphorylation amyloid precursor protein catabolic process negative regulation of apoptotic process regulation of protein binding positive regulation of MAP kinase activity negative regulation of neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis canonical Wnt signaling pathway negative regulation of protein phosphorylation positive regulation of protein phosphorylation myeloid leukocyte differentiation negative regulation of protein kinase activity proteolysis calcium ion transport cellular calcium ion homeostasis autophagy regulation of epidermal growth factor-activated receptor activity brain development heart development learning or memory cerebral cortex development neurogenesis neuron differentiation forebrain development segmentation locomotion eye photoreceptor cell development cellular protein metabolic process positive regulation of protein kinase activity beta-amyloid metabolic process protein maturation apoptotic process cell adhesion embryo development anagen
          It has to be done as per old AB suggested Products section.
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