Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000-1:6,000 | View 5 publications 5 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Profilin 1 Fusion Protein Ag2286 (1-140 aa encoded by BC006768) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.37 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MAGWNAYID NLMADGTCQD AAIVGYKDSP SVWAAVPGKT FVNITPAEVG VLVGKDRSSF YVNGLTLGGQ KCSVIRDSLL QDGEFSMDLR TKSTGGAPTF NVTVTKTDKT LVLLMGKEGV HGGLINKKCY EMASHLRRSQ Y (1-140 aa encoded by BC006768)
Profilin is an ubiquitous small (12-15 kDa) phosphoinositides and poly-L-proline binding protein that plays a role in both signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties but different expression patterns. Profilin I appears to be highly expressed in most tissues except for skeletal muscle. Profilin II is predominantly expressed in brain and at lower levels in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: actin binding protein; Epididymis tissue protein Li 184a; Profilin I; Profilin-1
Gene Aliases: ALS18; Pfn; PFN1
UniProt ID: (Human) P07737, (Rat) P62963, (Mouse) P62962
Entrez Gene ID: (Human) 5216, (Rat) 64303, (Mouse) 18643
Molecular Function:
actin or actin-binding cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein
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