|Tested species reactivity||Human|
|Published species reactivity||Hamster, Mouse, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein encoding human progesterone receptor 412-526 aa|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 3 publications below|
PA5-16709 targets Progesterone Receptor in IHC (P) applications and shows reactivity with Human samples.
The PA5-16709 immunogen is recombinant protein encoding human progesterone receptor 412-526 aa.
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
TGFBR1 is required for mouse myometrial development.
PA5-16709 was used in immunohistochemistry to study the role of TGFBR1 for mouse myometrial development
|Gao Y,Bayless KJ,Li Q||Molecular endocrinology (Baltimore, Md.) (28:380)||2014|
Progesterone receptor expression in the brain of the socially monogamous and paternal male prairie vole.
PA5-16709 was used in immunohistochemistry to study the effects of testosterone on the expression of the progesterone receptor in the brain of a monogamous spontaneously paternal male rodent species
|Williams B,Northcutt KV,Rusanowsky RD,Mennella TA,Lonstein JS,Quadros-Mennella PS||Brain research (1499:12)||2013|
Evolutionary pathways in BRCA1-associated breast tumors.
PA5-16709 was used in immunohistochemistry to study the loss of BRCA1, PTEN and TP53 in BRCA1-associated breast cancers and the implications for therapeutic intervention
|Martins FC,De S,Almendro V,Gönen M,Park SY,Blum JL,Herlihy W,Ethington G,Schnitt SJ,Tung N,Garber JE,Fetten K,Michor F,Polyak K||Cancer discovery (2:503)||2012|
Nucleoside, nucleotide and nucleic acid metabolism mRNA transcription mRNA transcription regulation Signal transduction Cell communication Steroid hormone-mediated signaling Oncogenesis Other oncogenesis Neuronal activities Other neuronal activity