Invitrogen

Progesterone Receptor Polyclonal Antibody

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Progesterone Receptor Antibody in Western Blot (WB) — Western blot analysis of Progesterone-Receptor on mouse thymus tissue. The sample was probed with a Progesterone-Receptor polyclonal antibody (Product # PA5-68778) using a primary antibody dilution of 0.2-1.0 µg/mL.

Product Details

Tested Applications

Dilution

Western Blot (WB)

0.2-1.0 µg/mL

Product Specifications

Species Reactivity

Dog, Guinea pig, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

synthetic peptide directed towards the middle region of mouse Progesterone Receptor

Conjugate

Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2689394

Product Specific Information

This target displays homology in the following species: Dog: 91%; Guinea Pig: 91%; Mouse: 100%; Rat: 91%

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: NR3C3; Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor; progesterone receptor A

Gene Aliases: 9930019P03Rik; BB114106; ENSMUSG00000074510; NR3C3; PGR; PR; PR-A; PR-B

UniProt ID: (Dog) Q9GLW0, (Rat) Q63449, (Mouse) Q00175

Entrez Gene ID: (Dog) 403621, (Rat) 25154, (Guinea pig) 100724945, (Mouse) 18667

Molecular Function: nuclear hormone receptor nucleic acid binding receptor transcription factor

transcription, DNA-templated regulation of transcription, DNA-templated steroid hormone mediated signaling pathway ovulation from ovarian follicle luteinization epithelial cell maturation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of cell proliferation negative regulation of gene expression positive regulation of smooth muscle cell migration diterpenoid metabolic process intracellular receptor signaling pathway mammary gland development response to progesterone response to cocaine negative regulation of apoptotic process response to estrogen estrous cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of epithelial cell proliferation progesterone receptor signaling pathway female mating behavior tertiary branching involved in mammary gland duct morphogenesis cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus paracrine signaling lung alveolus development

Process(es)

DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity steroid binding zinc ion binding sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding enzyme binding hormone binding lipid binding metal ion binding ATPase binding