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Invitrogen
Progesterone Receptor Antibody Cocktail
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FIGURE: 1 / 7
Progesterone Receptor Antibody (MA1-12626) in ICC/IF
Immunofluorescence analysis of Progesterone Receptor was performed using 70% confluent log phase T-47D cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Progesterone Receptor Monoclonal Antibody (hPRa2 + hPRa3) (Product # MA1-12626) at 1:100 dilution in... View More
Product Details
MA1-12626
Applications
Tested Dilution
Publications
Product Specifications
Published species
Bovine,
Cat,
Chicken,
Deer,
Horse,
Human,
Mouse,
Rhesus monkey,
Sheep
Host/Isotype
Mouse
/ IgG
Class
Cocktail
Type
Antibody
Clone
hPRa2, hPRa3
Immunogen
Human endometrial carcinoma from in athymic mice.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-12626 detects Progesterone Receptor in human, equine and porcine samples.
MA1-12626 has been successfully used in immunofluorescence, immunoprecipitation, western blot and immunohistochemistry (paraffin, frozen) procedures.
The MA1-12626 immunogen is human endometrial carcinoma from in athymic mice.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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