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Proteintech
Prohibitin 2 Polyclonal Antibody
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Product Details
12295-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Plant,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Prohibitin 2 Fusion Protein Ag2977 (1-299 aa encoded by BC014766)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAQNLKDLA GRLPAGPRGM GTALKLLLGA GAVAYGVRES VFTVEGGHRA IFFNRIGGVQ QDTILAEGLH FRIPWFQYPI IYDIRARPRK ISSPTGSKDL QMVNISLRVL SRPNAQELPS MYQRLGLDYE ERVLPSIVNE VLKSVVAKFN ASQLITQRAQ VSLLIRRELT ERAKDFSLIL DDVAITELSF SREYTAAVEA KQVAQQEAQR AQFLVEKAKQ EQRQKIVQAE GEAEAAKMLG EALSKNPGYI KLRKIRAAQN ISKTIATSQN RIYLTADNLV LNLQDESFTR GSDSLIKGKK (1-299 aa encoded by BC014766)
Target Information
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B cell receptor associated protein 37; B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; MGC117268; NB4 apoptosis/differentiation related protein; phb2; Prohibitin-2; Repressor of estrogen receptor activity; unnamed protein product
Gene Aliases: AU044498; BAP; Bap37; BCAP37; hBAP; p22; PHB2; PNAS-141; REA
UniProt ID: (Human) Q99623, (Mouse) O35129
Entrez Gene ID: (Human) 11331, (Mouse) 12034
mitophagy
positive regulation of immunoglobulin production
protein import into nucleus
mitochondrion organization
sister chromatid cohesion
cell migration
regulation of complement activation
intracellular estrogen receptor signaling pathway
negative regulation of intracellular estrogen receptor signaling pathway
mammary gland epithelial cell proliferation
negative regulation of mammary gland epithelial cell proliferation
RIG-I signaling pathway
B cell activation
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of ERK1 and ERK2 cascade
antiviral innate immune response
regulation of cardiolipin metabolic process
positive regulation of NIK/NF-kappaB signaling
regulation of cytochrome-c oxidase activity
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of exit from mitosis
positive regulation of cell cycle G1/S phase transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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