MA5-15899 targets PHB in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15899 immunogen is purified recombinant fragment of human PHB expressed in E. Coli. .
MA5-15899 detects PHB which has a predicted molecular weight of approximately 30kDa.
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-cell receptor-associated protein 32; BAP 32; epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; Prohibitin
Gene Aliases: Bap32; HEL-215; HEL-S-54e; PHB; PHB1