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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (KLH conjugated) to the C-terminus.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
OPA1-15292 detects the prokineticin receptor 2 (GPR73B) from human samples.
OPA1-15292 has been successfully used in immunohistochemistry procedures. By immunohistochemistry, OPA1-15292 detects the prokineticin receptor 2 (GPR73B) in formalin fixed, paraffin embedded human tissues.
The OPA1-15292 immunogen is a synthetic peptide (KLH conjugated) to the C-terminus.
Prokineticin receptor 2 (GPR73B) expression has been reported in brain, ovary, salivary gland, small intestine (ileocecum), testis, and thyroid. No human ESTs have been identified.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
G protein-coupled receptor 73-like 1; G-protein coupled receptor I5E; GPR73B; PK-R2
dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3; KAL3; PKR2; PROKR2