Immunogen sequence: QLPPGKPEIF KCRSPNKETF TCWWRPGTDG GLPTNYSLTY HREGETLMHE CPDYITGGPN SCHFGKQYTS MWRTYIMMVN ATNQMGSSFS DELYVDVTYI VQPDPPLELA VEVKQPEDRK PYLWIKWSPP TLIDLKTGWF TLLYEIRLKP EKAAEWEIHF AGQQTEFKIL SLHPGQKYLV QVRCKPDHGY WSAWSPATFI QIPSDFTMND; Positive Samples: 293T, MCF-7, Mouse ovary; Cellular Location: Membrane, Single-pass type I membrane protein
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
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Protein Aliases: hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; secreted prolactin binding protein
Gene Aliases: AI987712; HPRL; hPRLrI; MFAB; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR