Invitrogen

Protein APC Polyclonal Antibody

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Protein APC Polyclonal Antibody

Product Details

PA5-96213

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_0000292)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.99 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808015

Product Specific Information

Immunogen sequence: QSKENQVSAK GTWRKIKENE FSPTNSTSQT VSSGATNGAE SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT PPVIDSVSEK ANPNIKDSKD NQAKQNVGNG SVPMRTVGLE NRLNSFIQVD APDQKGTEIK PGQNNPVPVS ETNESSIVER T

Positive Samples: HeLa; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FAP; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator

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Gene Aliases: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC

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UniProt ID: (Human) P25054, (Rat) P70478

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Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205

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Function(s)
protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding protein complex binding gamma-catenin binding cadherin binding microtubule plus-end binding protease binding
Process(es)
mitotic cytokinesis kidney development hair follicle development protein complex assembly cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process axonogenesis negative regulation of cell proliferation axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAPK cascade skin development canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation regulation of nitrogen compound metabolic process chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of canonical Wnt signaling pathway regulation of glutamate metabolic process pancreas development response to drug response to alcohol cellular response to nerve growth factor stimulus cell fate specification cellular component disassembly involved in execution phase of apoptosis cell adhesion proteasome-mediated ubiquitin-dependent protein catabolic process bicellular tight junction assembly beta-catenin destruction complex assembly beta-catenin destruction complex disassembly
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