This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 80%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 86%; Rat: 86%; Sheep: 93%
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
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Protein Aliases: Activation peptide fragment 1; Activation peptide fragment 2; coagulation factor 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease; thrombin; Thrombin heavy chain; Thrombin light chain; THROMBIN protein
Gene Aliases: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1