Immunogen sequence: FEALESSTAT DVFWAKYTAC ETARTPRDKL AACLEGNCAE GLGTNYRGHV NITRSGIECQ LWRSRYPHKP EINSTTHPGA DLQ
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
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Protein Aliases: Activation peptide fragment 1; Activation peptide fragment 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease; Thrombin heavy chain; Thrombin light chain
Gene Aliases: F2; PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147