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Invitrogen
Protogenin Polyclonal Antibody
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Product Details
PA5-148398
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human PRTG fragment
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Protogenin, encoded by the PRTG gene, is a cell surface protein that belongs to the immunoglobulin superfamily and plays a critical role in neural development. Protogenin is involved in cell adhesion and signaling pathways that regulate processes such as neurogenesis, neuronal migration, and the establishment of neural circuits during embryonic development. Its expression is predominantly observed in the developing nervous system, where it facilitates interactions between cells and the extracellular matrix, contributing to the proper formation of brain structures. Protogenin's function in regulating cellular communication is essential for maintaining the balance between stem cell renewal and differentiation in neural tissues. Dysregulation or mutations in the PRTG gene can lead to developmental abnormalities and have been investigated for their potential connections to neurodevelopmental disorders. Research continues to explore protogenin's mechanisms and interaction networks to better understand its contributions to neural development and its potential as a therapeutic target in developmental disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: immunoglobulin superfamily, DCC subclass, member 5; Protein Shen-Dan; Protogenin; protogenin homolog (Gallus gallus); shen-dan
Gene Aliases: IGDCC5; PRTG
UniProt ID: (Human) Q2VWP7
Entrez Gene ID: (Human) 283659
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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