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Invitrogen
Protogenin Polyclonal Antibody
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Product Details
PA5-56940
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Protogenin
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Immunogen sequence: HYIIDDLEPA SNYTFYIVAY MPMGASQMSD HVTQNTLEDV PLRPPEISLT SRSPTDILIS WLPIPAKYRR GQVVLYRLSF R
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 99%.
Target Information
Protogenin, encoded by the PRTG gene, is a cell surface protein that belongs to the immunoglobulin superfamily and plays a critical role in neural development. Protogenin is involved in cell adhesion and signaling pathways that regulate processes such as neurogenesis, neuronal migration, and the establishment of neural circuits during embryonic development. Its expression is predominantly observed in the developing nervous system, where it facilitates interactions between cells and the extracellular matrix, contributing to the proper formation of brain structures. Protogenin's function in regulating cellular communication is essential for maintaining the balance between stem cell renewal and differentiation in neural tissues. Dysregulation or mutations in the PRTG gene can lead to developmental abnormalities and have been investigated for their potential connections to neurodevelopmental disorders. Research continues to explore protogenin's mechanisms and interaction networks to better understand its contributions to neural development and its potential as a therapeutic target in developmental disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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