Immunogen sequence: RAEIKLKRAV EEVKKLLVPA AEGEDSLKKM QLMELAILNG TYRDANIKSP ALAFSLAATA QAAPRIITGP APVLPPAALR TPTPAGPTIM PLIRQIQTAV MPNGTPHPTA AIVPPGPEAG LIYTPYEYPY TLAPATSILE YPIEPSGVL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp586I0923; homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; HqkI; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; protein quaking-like; QK; QK3; QKI; QKI, KH domain containing, RNA binding; QKI-5 protein; quaking homolog, KH domain RNA binding; RNA binding protein HQK
Gene Aliases: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3; Qka1; QKI