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Immunogen sequence: LDGLNKTTAC YHHLVLTVGG SADSQDLRQE LQKTRQKAQE LAVSTCARLT AVLRDRGLAA DERAEFERLW VAFSGCLDLL EAD
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 84%.
The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: regulator of G protein signaling 9 binding protein; Regulator of G-protein signaling 9-binding protein; RGS9 anchor protein; RGS9-anchoring protein
Gene Aliases: PERRS; R9AP; RGS9; RGS9BP
UniProt ID: (Human) Q6ZS82
Entrez Gene ID: (Human) 388531
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