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Proteintech
RAB11A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
20229-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Dog,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to RAB11A, and has no cross reaction to RAB11B.
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 24KG; GTPase; RAB 11A, member oncogene family; rab-11; RAB11A; unnamed protein product
Gene Aliases: YL8
UniProt ID: (Human) P62491, (Mouse) P62492, (Rat) P62494
Entrez Gene ID: (Human) 8766, (Mouse) 53869, (Rat) 81830
exocytosis
microtubule-based movement
mitotic metaphase plate congression
positive regulation of epithelial cell migration
positive regulation of G2/M transition of mitotic cell cycle
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
endocytic recycling
regulation of cytokinesis
protein localization to cell surface
multivesicular body assembly
Golgi to plasma membrane protein transport
positive regulation of cilium assembly
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
protein localization to cilium
protein transmembrane transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
synaptic vesicle endosomal processing
amyloid-beta clearance by transcytosis
regulation of cilium assembly
positive regulation of protein localization to plasma membrane
positive regulation of mitotic cytokinetic process
regulation of protein localization to centrosome
protein localization to cleavage furrow
exosomal secretion
regulation of endocytic recycling
plasma membrane to endosome transport
vesicle-mediated transport to the plasma membrane
intracellular cholesterol transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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