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Invitrogen
RAB11A Polyclonal Antibody
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FIGURE: 1 / 13
RAB11A Antibody (71-5300) in ICC/IF
Immunofluorescence analysis of Ras-related protein Rab-11A was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with RAB11A Polyclonal Antibody (Product # 71-5300) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (... View More
Product Details
71-5300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Published species
Bacteria,
C. elegans,
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Rat,
Rhesus monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the C-terminal hypervariable region of the human Rab11a sequence. This peptide shares 10 of 17 residues with the related Rab11b protein.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This polyclonal antibody reacts specifically with the human Rab11A protein. Cross-reactivity with other Rab family members has not been detected.
Positive control: Human HEK-293 cells
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 24KG; RAB 11A, member oncogene family; Rab-11; rab11; rab11 GTP-binding protein; Ras-related protein Rab-11A; tubulovesicle-associated protein; YL8
Gene Aliases: RAB11; RAB11A; YL8
UniProt ID: (Dog) P62490, (Rabbit) P62493, (Human) P62491, (Rat) P62494, (Mouse) P62492
Entrez Gene ID: (Dog) 403957, (Rabbit) 100009072, (Human) 8766, (Rat) 81830, (Mouse) 53869
intracellular protein transport
exocytosis
mitotic metaphase plate congression
metabolic process
positive regulation of epithelial cell migration
regulation of multivesicular body size
positive regulation of G2/M transition of mitotic cell cycle
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
Rab protein signal transduction
multivesicular body assembly
positive regulation of axon extension
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
exosomal secretion
regulation of cytokinesis
amyloid-beta clearance by transcytosis
cytokinesis
renal water homeostasis
small GTPase mediated signal transduction
protein transport
plasma membrane to endosome transport
transport
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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