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Product Details
18843-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: putative Ras-related protein Rab-12; Rab-13; Ras-related protein Rab-12
Gene Aliases: 2900054P15Rik; AW555448; C77700; RAB12
UniProt ID: (Human) Q6IQ22, (Mouse) P35283
Entrez Gene ID: (Human) 201475, (Mouse) 19328
transport
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
small GTPase mediated signal transduction
endosome to lysosome transport
protein secretion
protein transport
positive regulation of macroautophagy
regulation of exocytosis
Rab protein signal transduction
cellular protein catabolic process
protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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