Proteintech

RAB2 Polyclonal Antibody

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Antibody Testing Data (12)

RAB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 12

RAB2 Antibody (15420-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 15420-1-AP (RAB2 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

15420-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB2 Fusion Protein Ag7708 (1-212 aa encoded by BC008929)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize both RAB2A and RAB2B.

Immunogen sequence: MAYAYLFKY IIIGDTGVGK SCLLLQFTDK RFQPVHDLTI GVEFGARMIT IDGKQIKLQI WDTAGQESFR SITRSYYRGA AGALLVYDIT RRDTFNHLTT WLEDARQHSN SNMVIMLIGN KSDLESRREV KKEEGEAFAR EHGLIFMETS AKTASNVEEA FINTAKEIYE KIQEGVFDIN NEANGIKIGP QHAATNATHA GNQGGQQAGG GCC (1-212 aa encoded by BC008929)

Target Information

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.

Cell reports

Schleinitz A,Pöttgen LA,Keren-Kaplan T,Pu J,Saftig P,Bonifacino JS,Haas A,Jeschke A

Tue Jan 31 00:00:00 EST 2023

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.

iScience

Xiang C,Chen P,Zhang Q,Li Y,Pan Y,Xie W,Sun J,Liu Z

Fri Aug 20 00:00:00 EDT 2021

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.

iScience

Xiang C,Chen P,Zhang Q,Li Y,Pan Y,Xie W,Sun J,Liu Z

Fri Aug 20 00:00:00 EDT 2021

Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle.

mBio

Smith EP,Cotto-Rosario A,Borghesan E,Held K,Miller CN,Celli J

Tue Mar 31 00:00:00 EDT 2020

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

Journal of hematology & oncology

Lian X,Lin YM,Kozono S,Herbert MK,Li X,Yuan X,Guo J,Guo Y,Tang M,Lin J,Huang Y,Wang B,Qiu C,Tsai CY,Xie J,Gao ZJ,Wu Y,Liu H,Zhou XZ,Lu KP,Chen Y

Wed May 30 00:00:00 EDT 2018

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

Journal of hematology & oncology

Lian X,Lin YM,Kozono S,Herbert MK,Li X,Yuan X,Guo J,Guo Y,Tang M,Lin J,Huang Y,Wang B,Qiu C,Tsai CY,Xie J,Gao ZJ,Wu Y,Liu H,Zhou XZ,Lu KP,Chen Y

Wed May 30 00:00:00 EDT 2018

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.

Nature communications

Kozono S,Lin YM,Seo HS,Pinch B,Lian X,Qiu C,Herbert MK,Chen CH,Tan L,Gao ZJ,Massefski W,Doctor ZM,Jackson BP,Chen Y,Dhe-Paganon S,Lu KP,Zhou XZ

Thu Aug 09 00:00:00 EDT 2018

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.

Nature communications

Kozono S,Lin YM,Seo HS,Pinch B,Lian X,Qiu C,Herbert MK,Chen CH,Tan L,Gao ZJ,Massefski W,Doctor ZM,Jackson BP,Chen Y,Dhe-Paganon S,Lu KP,Zhou XZ

Thu Aug 09 00:00:00 EDT 2018

A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.

Cell host & microbe

Miller CN,Smith EP,Cundiff JA,Knodler LA,Bailey Blackburn J,Lupashin V,Celli J

Wed Sep 13 00:00:00 EDT 2017

A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.

Cell host & microbe

Miller CN,Smith EP,Cundiff JA,Knodler LA,Bailey Blackburn J,Lupashin V,Celli J

Wed Sep 13 00:00:00 EDT 2017

Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.

Journal of cell science

Matsunaga K,Taoka M,Isobe T,Izumi T

Wed Feb 01 00:00:00 EST 2017

Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.

Journal of cell science

Matsunaga K,Taoka M,Isobe T,Izumi T

Wed Feb 01 00:00:00 EST 2017

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

Proceedings of the National Academy of Sciences of the United States of America

Chen L,Chen Q,Xie B,Quan C,Sheng Y,Zhu S,Rong P,Zhou S,Sakamoto K,MacKintosh C,Wang HY,Chen S

Tue Jun 28 00:00:00 EDT 2016

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

Proceedings of the National Academy of Sciences of the United States of America

Chen L,Chen Q,Xie B,Quan C,Sheng Y,Zhu S,Rong P,Zhou S,Sakamoto K,MacKintosh C,Wang HY,Chen S

Tue Jun 28 00:00:00 EDT 2016

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

EMBO reports

Kajiho H,Kajiho Y,Frittoli E,Confalonieri S,Bertalot G,Viale G,Di Fiore PP,Oldani A,Garre M,Beznoussenko GV,Palamidessi A,Vecchi M,Chavrier P,Perez F,Scita G

Fri Jul 01 00:00:00 EDT 2016

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

EMBO reports

Kajiho H,Kajiho Y,Frittoli E,Confalonieri S,Bertalot G,Viale G,Di Fiore PP,Oldani A,Garre M,Beznoussenko GV,Palamidessi A,Vecchi M,Chavrier P,Perez F,Scita G

Fri Jul 01 00:00:00 EDT 2016

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.

Journal of neurochemistry

Ueda N,Tomita T,Yanagisawa K,Kimura N

Sun May 01 00:00:00 EDT 2016

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Cell reports

Luo ML,Gong C,Chen CH,Hu H,Huang P,Zheng M,Yao Y,Wei S,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

Tue Apr 07 00:00:00 EDT 2015

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Cell reports

Luo ML,Gong C,Chen CH,Hu H,Huang P,Zheng M,Yao Y,Wei S,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

Tue Apr 07 00:00:00 EDT 2015

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Cell reports

Luo ML,Gong C,Chen CH,Hu H,Huang P,Zheng M,Yao Y,Wei S,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

Tue Apr 07 00:00:00 EDT 2015

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Cell reports

Luo ML,Gong C,Chen CH,Hu H,Huang P,Zheng M,Yao Y,Wei S,Wulf G,Lieberman J,Zhou XZ,Song E,Lu KP

Tue Apr 07 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: GTP-binding protein; GTP-binding protein RAB2B; rab 2; RAB2, member RAS oncogene family; RAS family, member RAB2B; Ras-related protein Rab-2A; Ras-related protein Rab-2B; small GTP binding protein RAB2A

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Gene Aliases: 1500012D09Rik; 4930528G15Rik; 9330148M11Rik; A230002G14; C80220; D530043M21Rik; LHX; RAB2; RAB2A; RAB2B

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UniProt ID: (Human) P61019, (Human) Q8WUD1, (Mouse) P53994, (Rat) P05712, (Mouse) P59279

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Entrez Gene ID: (Human) 5862, (Human) 84932, (Mouse) 59021, (Rat) 65158, (Rat) 305853, (Mouse) 76338

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Function(s)

GTPase activity protein binding GTP binding GDP binding nucleotide binding

Process(es)

ER to Golgi vesicle-mediated transport Golgi organization small GTPase mediated signal transduction protein transport transport intracellular protein transport metabolic process vesicle-mediated transport Rab protein signal transduction positive regulation of exocytosis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB2 Polyclonal Antibody

RAB2 Antibody (15420-1-AP) in IHC (P)

Product Details

15420-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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