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Product Details
PA5-53528
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAB21
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646225
Product Specific Information
Immunogen sequence: GAILVYDITD EDSFQKVKNW VKELRKMLGN EICLCIVGNK IDLEKERHVS IQEAESYAES VGAKHYHTSA KQNKGIEELF LDLCKRMIET AQVDERAKGN GSSQPGTARR GVQIIDDEPQ AQTS
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
Target Information
RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein RAB21; Ras-related protein Rab-21
Gene Aliases: KIAA0118; RAB21
UniProt ID: (Human) Q9UL25
Entrez Gene ID: (Human) 23011
small GTPase mediated signal transduction
anterograde axonal transport
protein transport
regulation of exocytosis
regulation of axon extension
positive regulation of receptor-mediated endocytosis
positive regulation of dendrite morphogenesis
positive regulation of early endosome to late endosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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