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RAB3A Polyclonal Antibody

View all (23) RAB3a antibodies

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RAB3A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using (Product # 15029-1-AP) (RAB3A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

RAB3A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human gliomas using 15029-1-AP (RAB3A antibody) at dilution of 1:100 (under 40x lens).

RAB3A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human gliomas using 15029-1-AP (RAB3A antibody) at dilution of 1:100 (under 10x lens).

RAB3A Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 15029-1-AP (RAB3A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RAB3A Antibody in Immunoprecipitation (IP) — IP result of anti-RAB3A (IP:15029-1-AP, 4ug; Detection:15029-1-AP 1:1000) with mouse brain tissue lysate 4000ug.

Product Details

15029-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:4,000	View 4 publications 4 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunoprecipitation (IP)	0.5-4.0 µg	-
Immunohistochemistry (IHC)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	RAB3A Fusion Protein Ag1903 (1-220 aa encoded by BC011782) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.37 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MASATDSRY GQKESSDQNF DYMFKILIIG NSSVGKTSFL FRYADDSFTP AFVSTVGIDF KVKTIYRNDK RIKLQIWDTA GQERYRTITT AYYRGAMGFI LMYDITNEES FNAVQDWSTQ IKTYSWDNAQ VLLVGNKCDM EDERVVSSER GRQLADHLGF EFFEASAKDN INVKQTFERL VDVICEKMSE SLDTADPAVT GAKQGPQLSD QQVPPHQDCA C (1-220 aa encoded by BC011782)

Target Information

Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has 4 known isoforms: 3A, 3B, 3C, and 3D. These proteins are expressed in highest concentrations in brain and endocrine tissues and involved in regulated exocytosis of hormones and neurotransmitters. Specifically, Rab 3s are thought to play a key role in presynaptic vesicle trafficking and priming.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 EDT 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 EDT 2018

Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7.

Biochemical pharmacology

Liu S,Sahid MNA,Takemasa E,Maeyama K,Mogi M

Tue May 01 00:00:00 EDT 2018

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.

Molecular cancer

Chang YC,Su CY,Chen MH,Chen WS,Chen CL,Hsiao M

Mon Aug 07 00:00:00 EDT 2017

RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.

PloS one

Wang H,Wang R,Xu S,Lakshmana MK

Wed Sep 17 00:00:00 EDT 2014

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lakshmana MK,Hayes CD,Bennett SP,Bianchi E,Reddy KM,Koo EH,Kang DE

Tue May 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: C18A3.6; RAS-associated protein RAB3A; Ras-related protein Rab-3A; Ras-related small GTP binding protein 3A

Gene Aliases: RAB3; RAB3A

UniProt ID: (Human) P20336, (Rat) P63012, (Mouse) P63011

Entrez Gene ID: (Human) 5864, (Rat) 25531, (Mouse) 19339

respiratory system process intracellular protein transport vesicle docking involved in exocytosis mitochondrion organization neuromuscular synaptic transmission axonogenesis metabolic process protein secretion post-embryonic development synaptic vesicle exocytosis synaptic vesicle maturation regulation of exocytosis lung development regulation of synaptic vesicle fusion to presynaptic membrane Rab protein signal transduction positive regulation of ATPase activity synaptic vesicle recycling regulation of short-term neuronal synaptic plasticity maintenance of presynaptic active zone structure sensory perception of touch response to electrical stimulus protein localization to plasma membrane positive regulation of regulated secretory pathway transport exocytosis small GTPase mediated signal transduction protein transport synaptic vesicle transport evoked neurotransmitter secretion regulation of long-term synaptic potentiation neurotransmitter secretion glutamate secretion constitutive secretory pathway positive regulation of exocytosis

Process(es)

ATPase activator activity GTPase activity protein binding GTP binding protein C-terminus binding myosin V binding GTPase binding ATPase binding GDP binding nucleotide binding