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Proteintech
RAB3GAP1 Polyclonal Antibody
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Product Details
21663-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Monkey,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RAB3GAP1 Fusion Protein Ag16426 (502-851 aa encoded by BC146809)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PGDAGKAGD QLVPDNLKET DKEKGEVGKS WDSWSDSEEE FFECLSDTEE LKGNGQESGK KGGPKEMANL RPEGRLYQHG KLTLLHNGEP LYIPVTQEPA PMTEDLLEEQ SEVLAKLGTS AEGAHLRARM QSACLLSDME SFKAANPGCS LEDFVRWYSP RDYIEEEVID EKGNVVLKGE LSARMKIPSN MWVEAWETAK PIPARRQRRL FDDTREAEKV LHYLAIQKPA DLARHLLPCV IHAAVLKVKE EESLENISSV KKIIKQIISH SSKVLHFPNP EDKKLEEIIH QITNVEALIA RARSLKAKFG TEKCEQEEEK EDLERFVSCL LEQPEVLVTG AGRGHAGRII H (502-851 aa encoded by BC146809)
Target Information
RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: KIAA0066; Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130
Gene Aliases: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; MARTS2; P130; RAB3GAP; RAB3GAP1; RAB3GAP130; WARBM1
UniProt ID: (Human) Q15042, (Mouse) Q80UJ7
Entrez Gene ID: (Human) 22930, (Mouse) 226407
brain development
hypothalamus development
Rab protein signal transduction
lipid particle organization
camera-type eye development
regulation of GTPase activity
positive regulation of GTPase activity
regulation of short-term neuronal synaptic plasticity
excitatory postsynaptic potential
face morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
establishment of protein localization to endoplasmic reticulum membrane
positive regulation of protein lipidation
regulation of calcium ion-dependent exocytosis of neurotransmitter
positive regulation of endoplasmic reticulum tubular network organization
positive regulation of autophagosome assembly
positive regulation of gene expression
regulation of synaptic vesicle priming
synaptic vesicle transport
protein stabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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