Proteintech

RAB3GAP1 Polyclonal Antibody

RAB3GAP1 Antibody in Immunocytochemistry (ICC/IF)

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RAB3GAP1 Antibody (21663-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using RAB3GAP1 antibody 21663-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

RAB3GAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RAB3GAP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21663-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB3GAP1 Fusion Protein Ag16426 (502-851 aa encoded by BC146809)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PGDAGKAGD QLVPDNLKET DKEKGEVGKS WDSWSDSEEE FFECLSDTEE LKGNGQESGK KGGPKEMANL RPEGRLYQHG KLTLLHNGEP LYIPVTQEPA PMTEDLLEEQ SEVLAKLGTS AEGAHLRARM QSACLLSDME SFKAANPGCS LEDFVRWYSP RDYIEEEVID EKGNVVLKGE LSARMKIPSN MWVEAWETAK PIPARRQRRL FDDTREAEKV LHYLAIQKPA DLARHLLPCV IHAAVLKVKE EESLENISSV KKIIKQIISH SSKVLHFPNP EDKKLEEIIH QITNVEALIA RARSLKAKFG TEKCEQEEEK EDLERFVSCL LEQPEVLVTG AGRGHAGRII H (502-851 aa encoded by BC146809)

Target Information

RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap1.

JACC. Basic to translational science

Essandoh K,Subramani A,Ferro OA,Teuber JP,Koripella S,Brody MJ

Mon May 01 00:00:00 UTC 2023

zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap1.

JACC. Basic to translational science

Essandoh K,Subramani A,Ferro OA,Teuber JP,Koripella S,Brody MJ

Mon May 01 00:00:00 UTC 2023

Global effects of RAB3GAP1 dysexpression on the proteome of mouse cortical neurons.

Amino acids

Liu Y,Tian F,Li S,Chen W,Gong W,Xie H,Liu D,Huang R,Liao W,Yi F,Zhou J

Wed Sep 01 00:00:00 UTC 2021

A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells.

Cell death & disease

Konishi H,Fujiya M,Kashima S,Sakatani A,Dokoshi T,Ando K,Ueno N,Iwama T,Moriichi K,Tanaka H,Okumura T

Fri Apr 17 00:00:00 UTC 2020

Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons.

Toxicology letters

Wang TY,Ma Z,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu ZF,Xu B

Thu Mar 15 00:00:00 UTC 2018

Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons.

Toxicology letters

Wang TY,Ma Z,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu ZF,Xu B

Thu Mar 15 00:00:00 UTC 2018

Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons.

Toxicology letters

Wang TY,Ma Z,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu ZF,Xu B

Thu Mar 15 00:00:00 UTC 2018

Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons.

Toxicology letters

Wang TY,Ma Z,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu ZF,Xu B

Thu Mar 15 00:00:00 UTC 2018

COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.

The EMBO journal

Li C,Luo X,Zhao S,Siu GK,Liang Y,Chan HC,Satoh A,Yu SS

Wed Feb 15 00:00:00 UTC 2017

COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.

The EMBO journal

Li C,Luo X,Zhao S,Siu GK,Liang Y,Chan HC,Satoh A,Yu SS

Wed Feb 15 00:00:00 UTC 2017

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hong Y,Zhao T,Li XJ,Li S

Wed Aug 24 00:00:00 UTC 2016

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hong Y,Zhao T,Li XJ,Li S

Wed Aug 24 00:00:00 UTC 2016

Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.

Open biology

Handley MT,Carpanini SM,Mali GR,Sidjanin DJ,Aligianis IA,Jackson IJ,FitzPatrick DR

Mon Jun 01 00:00:00 UTC 2015

Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.

Open biology

Handley MT,Carpanini SM,Mali GR,Sidjanin DJ,Aligianis IA,Jackson IJ,FitzPatrick DR

Mon Jun 01 00:00:00 UTC 2015

Rab18 and a Rab18 GEF complex are required for normal ER structure.

The Journal of cell biology

Gerondopoulos A,Bastos RN,Yoshimura S,Anderson R,Carpanini S,Aligianis I,Handley MT,Barr FA

Mon Jun 09 00:00:00 UTC 2014

Rab18 and a Rab18 GEF complex are required for normal ER structure.

The Journal of cell biology

Gerondopoulos A,Bastos RN,Yoshimura S,Anderson R,Carpanini S,Aligianis I,Handley MT,Barr FA

Mon Jun 09 00:00:00 UTC 2014

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

BMC biology

Baron Y,Pedrioli PG,Tyagi K,Johnson C,Wood NT,Fountaine D,Wightman M,Alexandru G

Thu May 29 00:00:00 UTC 2014

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

BMC biology

Baron Y,Pedrioli PG,Tyagi K,Johnson C,Wood NT,Fountaine D,Wightman M,Alexandru G

Thu May 29 00:00:00 UTC 2014

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

BMC biology

Baron Y,Pedrioli PG,Tyagi K,Johnson C,Wood NT,Fountaine D,Wightman M,Alexandru G

Thu May 29 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130

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Gene Aliases: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; P130; RAB3GAP; RAB3GAP1; RAB3GAP130; WARBM1

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UniProt ID: (Human) Q15042, (Mouse) Q80UJ7

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Entrez Gene ID: (Human) 22930, (Mouse) 226407

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Function(s)

guanyl-nucleotide exchange factor activity GTPase activator activity Rab guanyl-nucleotide exchange factor activity Rab GTPase binding GTPase-activating protein

Process(es)

brain development positive regulation of gene expression hypothalamus development lipid particle organization camera-type eye development regulation of GTPase activity positive regulation of GTPase activity regulation of short-term neuronal synaptic plasticity excitatory postsynaptic potential face morphogenesis positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization establishment of protein localization to endoplasmic reticulum membrane positive regulation of protein lipidation regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of endoplasmic reticulum tubular network organization positive regulation of autophagosome assembly regulation of synaptic vesicle priming synaptic vesicle transport protein stabilization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB3GAP1 Polyclonal Antibody

RAB3GAP1 Antibody (21663-1-AP) in ICC/IF

Product Details

21663-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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