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RAB5 Polyclonal Antibody
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Product Details
BS-6175R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RAB5, amino acids 8-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab 5; Rab 5A; RAB5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A; Small GTP-binding protein rab5; unnamed protein product
Gene Aliases: 2410015H04Rik; AI663973; AU021172; nnyRab5a; RAB5; RAB5A
UniProt ID: (Human) P20339, (Mouse) Q9CQD1, (Rat) M0RC99
Entrez Gene ID: (Human) 5868, (Mouse) 271457, (Rat) 64633
intracellular protein transport
endocytosis
phagocytosis
protein transport
endosomal transport
receptor internalization
synaptic vesicle recycling
modulation by host of viral process
early endosome to late endosome transport
positive regulation of exocytosis
regulation of long-term neuronal synaptic plasticity
plasma membrane to endosome transport
regulation of endosome size
regulation of filopodium assembly
canonical Wnt signaling pathway
membrane fusion
amyloid-beta clearance by transcytosis
protein localization to early endosome
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
transport
endosome organization
small GTPase mediated signal transduction
positive regulation of smooth muscle cell migration
regulation of endocytosis
Rab protein signal transduction
positive regulation of smooth muscle cell proliferation
receptor internalization involved in canonical Wnt signaling pathway
vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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