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Invitrogen
RAB5 Polyclonal Antibody
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Product Details
PA3-915
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant human Rab5.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-915 detects Rab5 from human and rat samples.
PA3-915 has been successfully used in Western blot and immunofluorescence procedures.
The PA3-915 immunogen is recombinant human Rab5.
Target Information
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Rab 5; Rab 5A; RAB5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A; Small GTP-binding protein rab5; unnamed protein product
Gene Aliases: RAB5; RAB5A
UniProt ID: (Human) P20339, (Rat) M0RC99
Entrez Gene ID: (Human) 5868, (Rat) 64633
intracellular protein transport
endocytosis
phagocytosis
protein transport
endosomal transport
receptor internalization
synaptic vesicle recycling
modulation by host of viral process
early endosome to late endosome transport
positive regulation of exocytosis
regulation of long-term neuronal synaptic plasticity
plasma membrane to endosome transport
regulation of endosome size
regulation of filopodium assembly
canonical Wnt signaling pathway
membrane fusion
amyloid-beta clearance by transcytosis
protein localization to early endosome
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
endosome organization
small GTPase mediated signal transduction
positive regulation of smooth muscle cell migration
vesicle-mediated transport
positive regulation of smooth muscle cell proliferation
receptor internalization involved in canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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