This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: CVLVFDVTAP NTFKTLDSWR DEFLIQASPR DPENFPFVVL GNKIDLENRQ VATKRAQAWC YSKNNIPYFE TSAKEAINVE QAFQTIARNA LKQETEVELY NEFPEPIKLD KNDRAK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
Rab7 is a 207 amino acid transport carrier, belonging to the Rab family of RAS-related GTP-binding proteins with 4 GTP/GDP-binding sites and terminates in sequences such as cys-X-cys, cys-cys or a closely related sequence. Rab7 located in specific intracellular compartments is known to be an important regulator of vesicular transport of proteins from early to late endosomes and lysosome biogenesis. Rab7 accelerates thyroid hormone production controlling aggregation and fusion of late lysosomes. It is ubiquitously expressed in most of the tissues and plays an essential role in maintenance of the perinuclear lysosome compartment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: member RAS oncogene family; PRO2706; RAB7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a
Gene Aliases: PRO2706; RAB7; RAB7A