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Invitrogen
RAB7B Polyclonal Antibody
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Product Details
PA5-49264
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human RAB7B.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ras-related protein Rab-7; Ras-related protein Rab-7b
Gene Aliases: RAB7; RAB7B
UniProt ID: (Human) Q96AH8
Entrez Gene ID: (Human) 338382
regulation of immune system process
endosome to lysosome transport
protein transport
positive regulation of interleukin-6 production
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 9 signaling pathway
late endosome to Golgi transport
positive regulation of megakaryocyte differentiation
positive regulation of NF-kappaB transcription factor activity
cellular response to interferon-gamma
phagosome-lysosome fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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