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Invitrogen

RAC1/RAC2/RAC3 Recombinant Rabbit Monoclonal Antibody (2J4S6)

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RAC1/RAC2/RAC3 Recombinant Rabbit Monoclonal Antibody (2J4S6)

Product Details

MA5-35636

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2J4S6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human RAC1(P63000)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.6 mg/mL

Amount

160 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849536

Product Specific Information

Immunogen sequence: MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKC

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cell migration-inducing gene 5 protein; EN-7 protein; GX; p21-Rac1; p21-Rac2; p21-Rac3; Protein EN-7; Ras-like protein TC25; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); rho family, small GTP binding protein Rac1; Small G protein

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Gene Aliases: AI323801; AI452260; AL023026; D5Ertd559e; MIG5; Rac; RAC1; Rac1B; RAC2; RAC3; TC25

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UniProt ID: (Mouse) P63001, (Rat) Q6RUV5, (Mouse) Q05144, (Mouse) P60764

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Entrez Gene ID: (Mouse) 19353, (Rat) 363875, (Rat) 366957, (Mouse) 19354, (Mouse) 170758, (Rat) 688319

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Function(s)
nucleotide binding GTPase activity protein binding GTP binding Rab GTPase binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding histone deacetylase binding Rho GDP-dissociation inhibitor binding calcium-dependent protein binding small GTPase immunoglobulin
Process(es)
positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis endocytosis phagocytosis, engulfment chemotaxis hyperosmotic response cytoskeleton organization actin filament organization cell adhesion G-protein coupled receptor signaling pathway small GTPase mediated signal transduction axon guidance metabolic process cell proliferation positive regulation of lamellipodium assembly regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation dendrite development cell migration cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development regulation of cell morphogenesis lamellipodium assembly actin cytoskeleton organization actin filament polymerization regulation of cell migration positive regulation of actin filament polymerization ruffle organization negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell cell-cell junction organization bone resorption positive regulation of DNA replication anatomical structure arrangement dendrite morphogenesis cell motility homeostasis of number of cells within a tissue positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly synaptic transmission, GABAergic Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly positive regulation of substrate adhesion-dependent cell spreading Rac protein signal transduction positive regulation of cell proliferation regulation of cell-substrate adhesion cell projection assembly lymphocyte aggregation regulation of neutrophil migration positive regulation of protein targeting to mitochondrion neuron projection development positive regulation of cell adhesion mediated by integrin neuromuscular process controlling balance neuromuscular process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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