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Invitrogen
RAC2 Polyclonal Antibody
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FIGURE: 1 / 6
RAC2 Antibody (PA5-88121) in IHC (P)
Immunohistochemistry analysis of RAC2 in paraffin-embedded human esophagus. Samples were incubated with RAC2 Polyclonal antibody (Product # PA5-88121) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-88121
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
3.35 mg/mL
Amount
335 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HL-60; Cellular Location: Cytoplasm
Immunogen sequence: MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRACS LL
Target Information
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EN-7 protein; GX; p21-Rac2; Protein EN-7; RAC2; RAS-related C3 botulinum substrate 2; ras-related C3 botulinum toxin substrate; Ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein
Gene Aliases: AI323801; AI452260; EN-7; Gx; HSPC022; IMD73A; IMD73B; IMD73C; p21-Rac2; RAC2
UniProt ID: (Human) P15153, (Mouse) Q05144
Entrez Gene ID: (Human) 5880, (Rat) 366957, (Mouse) 19354
chemotaxis
actin filament organization
establishment or maintenance of cell polarity
signal transduction
G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
cell proliferation
regulation of cell shape
regulation of hydrogen peroxide metabolic process
positive regulation of lamellipodium assembly
regulation of cell-substrate adhesion
cell projection assembly
actin cytoskeleton organization
cortical cytoskeleton organization
regulation of actin cytoskeleton organization
regulation of T cell proliferation
superoxide anion generation
erythrocyte enucleation
regulation of mast cell degranulation
bone resorption
respiratory burst
regulation of respiratory burst
regulation of mast cell chemotaxis
mast cell proliferation
positive regulation of mast cell proliferation
lymphocyte aggregation
positive regulation of neutrophil chemotaxis
regulation of neutrophil migration
positive regulation of protein targeting to mitochondrion
metabolic process
positive regulation of cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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