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Invitrogen

RACK1 Polyclonal Antibody

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1 Reference
View all (19) RACK1 antibodies

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Product Details

PA5-17484

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

-
- -

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Fruit fly, Human, Mouse, Rat, Zebrafish

Published species

Yeast

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to human RACK1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

29 µg/mL

Amount

2.9 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980517

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; CG7111-PA; CG7111-PB; CG7111-PC; CG7111-PD; GNB2L1; guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide binding protein, beta-2, related sequence 1; guanine nucleotide-binding protein beta-subunit like protein; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; protein kinase C receptor; RACK; rack-1; Rack1-PA; Rack1-PB; Rack1-PC; Rack1-PD; RE74715p; Receptor for activated C kinase; Receptor for activated C kinase 1; receptor for activated protein kinase C; receptor for activated protein kinase C1; receptor of activated PKC; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C; Receptor of activated protein kinase C 1; Receptor of activated protein kinase C homolog; similar to mammalian RACK1; Small ribosomal subunit protein RACK1; unnamed protein product

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Gene Aliases: AL033335; CG7111; Dmel\CG7111; Dmel_CG7111; dRack1; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; i173; p205; PIG21; RACK1; wu:fb80d08; wu:fk65d12

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UniProt ID: (Rat) P63245, (Mouse) P68040, (Human) P63244, (Fruit fly) O18640, (Zebrafish) O42248

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Entrez Gene ID: (Rat) 83427, (Mouse) 14694, (Human) 10399, (Fruit fly) 34070, (Zebrafish) 30722

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Function(s)
protein kinase C binding ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding SH2 domain binding protein homodimerization activity poly(A) RNA binding receptor activity protein binding signaling adaptor activity RNA binding receptor binding enzyme activator activity protein serine/threonine kinase inhibitor activity cyclin binding identical protein binding ribosome binding translation regulator activity cadherin binding BH3 domain binding binding, bridging
Process(es)
mRNA splicing, via spliceosome negative regulation of protein phosphorylation positive regulation of protein phosphorylation locomotory behavior cellular response to starvation regulation of autophagosome size oviposition positive regulation of actin filament polymerization wing disc development cuticle development positive regulation by host of viral genome replication positive regulation of glycogen biosynthetic process muscle cell cellular homeostasis oogenesis rescue of stalled ribosome IRES-dependent viral translational initiation osteoblast differentiation activation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase C-activating G-protein coupled receptor signaling pathway gastrulation negative regulation of gene expression negative regulation of translation negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of cell migration positive regulation of cAMP catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein homooligomerization regulation of protein localization positive regulation of apoptotic process positive regulation of GTPase activity rhythmic process negative regulation of phagocytosis regulation of cell division positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity regulation of establishment of protein localization to plasma membrane negative regulation of hydrogen peroxide-induced neuron death regulation of establishment of cell polarity positive regulation of gastrulation positive regulation of intrinsic apoptotic signaling pathway regulation of translation apoptotic process cell cycle multicellular organism development protein localization negative regulation of peptidyl-serine phosphorylation intracellular signal transduction regulation of growth cellular response to glucose stimulus angiogenesis convergent extension involved in gastrulation cytoplasmic translation translation protein ubiquitination positive regulation of protein complex assembly negative regulation of protein binding positive regulation of Golgi to plasma membrane protein transport pigmentation negative regulation of smoothened signaling pathway cellular response to growth factor stimulus regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of endoplasmic reticulum unfolded protein response negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of translational frameshifting
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