Invitrogen

RACK1 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

View all (22) RACK1 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-79319

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human RACK1 recombinant protein (Position: T2-R317).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2746435

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; protein kinase C receptor; rack-1; Receptor for activated C kinase; receptor for activated protein kinase C; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1

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Gene Aliases: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1

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UniProt ID: (Rat) P63245, (Mouse) P68040, (Human) P63244

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Entrez Gene ID: (Rat) 83427, (Mouse) 14694, (Human) 10399

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Function(s)
protein kinase C binding ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding SH2 domain binding protein homodimerization activity poly(A) RNA binding receptor activity protein binding signaling adaptor activity receptor binding protein complex scaffold cadherin binding involved in cell-cell adhesion
Process(es)
osteoblast differentiation positive regulation of protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase C-activating G-protein coupled receptor signaling pathway gastrulation negative regulation of gene expression negative regulation of translation negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of cell migration positive regulation of cAMP catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein homooligomerization regulation of protein localization positive regulation of apoptotic process positive regulation of GTPase activity rhythmic process negative regulation of phagocytosis regulation of cell division positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity regulation of establishment of protein localization to plasma membrane negative regulation of hydrogen peroxide-induced neuron death regulation of establishment of cell polarity positive regulation of gastrulation positive regulation of intrinsic apoptotic signaling pathway regulation of translation apoptotic process cell cycle multicellular organism development protein localization negative regulation of peptidyl-serine phosphorylation intracellular signal transduction regulation of growth cellular response to glucose stimulus regulation of tumor necrosis factor-mediated signaling pathway viral process positive regulation of Golgi to plasma membrane protein transport cellular response to growth factor stimulus cell-cell adhesion negative regulation of endoplasmic reticulum unfolded protein response positive regulation of ceramide biosynthetic process
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