Immunogen sequence: MILSASRDKT IIMWKLTRDE TNYGIPQRAL RGHSHFVSDV VISSDGQFAL SGSWDGTLRL WDLTTGTTTR RFVGHTKDVL SVAFSSDNRQ IVSGSRDKTI KLWNTLGVCK YTVQDESHSE WVSCVRFSPN SSNPIIVSCG WDKLVKVWNL ANCKLKTNHI GHTGYLNTVT VSPDGSLCAS GGKDGQAMLW DLNEGKHLYT LDGGDIINAL CFSPNRYWLC AATGPSIKIW DLEGKIIVDE LKQEVISTSS KAEPPQCTSL A; Positive Samples: MCF-7, 293T, Mouse spleen; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, cytoskeleton, dendrite, perinuclear region, phagocytic cup
RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.
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Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; p205; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; Receptor for activated C kinase; Receptor of activated protein C kinase 1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1
Gene Aliases: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1