Recommended positive controls: A431, Jurkat, Raji, HeLa.
Predicted reactivity: Human (99%), Mouse (92%), Rat (93%), Xenopus laevis (80%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
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Protein Aliases: B; HHR23B; HR23B; p58; RAD23; RAD23, yeast homolog of, B; UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein; yeast homolog of
Gene Aliases: HHR23B; HR23B; P58; RAD23B
UniProt ID: (Human) P54727
Entrez Gene ID: (Human) 5887