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Invitrogen
RAD23B Polyclonal Antibody
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Product Details
PA5-56236
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAD23B. Recombinant protein control fragment (Product #RP-95282).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VIEALRASFN NPDRAVEYLL MGIPGDRESQ AVVDPPQAAS TGAPQSSAVA AAAATTTATT TTTSSGGHPL EFLRNQPQFQ QMRQIIQQNP
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HR23B; p58; RAD23, yeast homolog of, B; UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein
Gene Aliases: HHR23B; HR23B; P58; RAD23B
UniProt ID: (Human) P54727
Entrez Gene ID: (Human) 5887
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
spermatogenesis
regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
embryonic organ development
global genome nucleotide-excision repair
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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