This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-31554 targets Rad50 in IHC (P) and WB applications and shows reactivity with Human and Mouse samples.
The PA5-31554 immunogen is recombinant fragment corresponding to a region within amino acids 128 and 420 of Human Rad50.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA repair protein RAD50; hRAD50; mRad50; NBSLD; RAD50 homolog, double strand break repair protein; RAD502
Gene Aliases: hRad50; Mrell; NBSLD; RAD50; RAD502; Rad50l
UniProt ID: (Human) Q92878