Product References
RAD51 is essential for spermatogenesis and male fertility in mice.
Cell death discovery
Qin J,Huang T,Wang J,Xu L,Dang Q,Xu X,Liu H,Liu Z,Shao C,Zhang X
Published figure using RAD51 polyclonal antibody (Product # PA5-27195) in Immunohistochemistry
Tue Mar 15 00:00:00 EDT 2022
RAD51 is essential for spermatogenesis and male fertility in mice.
Cell death discovery
Qin J,Huang T,Wang J,Xu L,Dang Q,Xu X,Liu H,Liu Z,Shao C,Zhang X
Published figure using RAD51 polyclonal antibody (Product # PA5-27195) in Immunohistochemistry
Tue Mar 15 00:00:00 EDT 2022
RAD51 is essential for spermatogenesis and male fertility in mice.
Cell death discovery
Qin J,Huang T,Wang J,Xu L,Dang Q,Xu X,Liu H,Liu Z,Shao C,Zhang X
Published figure using RAD51 polyclonal antibody (Product # PA5-27195) in Immunohistochemistry
Tue Mar 15 00:00:00 EDT 2022
Gut Microbiota Dysbiosis Accelerates Prostate Cancer Progression Through Increased LPCAT1 Expression and Enhanced DNA Repair Pathways.
Frontiers in oncology
Liu Y,Yang C,Zhang Z,Jiang H
PA5-27195 was used in Western Blot to determine the potential mechanism of microbiota dysbiosis in prostate cancer (PCa) progression.
Tue Jul 06 00:00:00 EDT 2021
Gut Microbiota Dysbiosis Accelerates Prostate Cancer Progression Through Increased LPCAT1 Expression and Enhanced DNA Repair Pathways.
Frontiers in oncology
Liu Y,Yang C,Zhang Z,Jiang H
PA5-27195 was used in Western Blot to determine the potential mechanism of microbiota dysbiosis in prostate cancer (PCa) progression.
Tue Jul 06 00:00:00 EDT 2021
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer.
Cell death & disease
Silva VL,Saxena J,Nicolini F,Hoare JI,Metcalf S,Martin SA,Lockley M
PA5-27195 was used in Immunocytochemistry, Western Blot to investigate the activity of chloroxine as an anticancer agent and its cellular mechanism as well as its synergy with platinum agents in resistant high-grade serous cancer both in vitro and in vivo.
Wed Apr 14 00:00:00 EDT 2021
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer.
Cell death & disease
Silva VL,Saxena J,Nicolini F,Hoare JI,Metcalf S,Martin SA,Lockley M
PA5-27195 was used in Immunocytochemistry, Western Blot to investigate the activity of chloroxine as an anticancer agent and its cellular mechanism as well as its synergy with platinum agents in resistant high-grade serous cancer both in vitro and in vivo.
Wed Apr 14 00:00:00 EDT 2021
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer.
Cell death & disease
Silva VL,Saxena J,Nicolini F,Hoare JI,Metcalf S,Martin SA,Lockley M
PA5-27195 was used in Immunocytochemistry, Western Blot to investigate the activity of chloroxine as an anticancer agent and its cellular mechanism as well as its synergy with platinum agents in resistant high-grade serous cancer both in vitro and in vivo.
Wed Apr 14 00:00:00 EDT 2021
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer.
Cell death & disease
Silva VL,Saxena J,Nicolini F,Hoare JI,Metcalf S,Martin SA,Lockley M
PA5-27195 was used in Immunocytochemistry, Western Blot to investigate the activity of chloroxine as an anticancer agent and its cellular mechanism as well as its synergy with platinum agents in resistant high-grade serous cancer both in vitro and in vivo.
Wed Apr 14 00:00:00 EDT 2021
MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.
Nucleic acids research
Shang Y,Huang T,Liu H,Liu Y,Liang H,Yu X,Li M,Zhai B,Yang X,Wei Y,Wang G,Chen Z,Wang S,Zhang L
PA5-27195 was used in Immunohistochemistry to investigate if MEIOK21 is a component of meiotic recombination bridges and thus required for efficient formation of DMC1/RAD51 foci.
Thu Jul 09 00:00:00 EDT 2020
The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.
eLife
Huang T,Yuan S,Gao L,Li M,Yu X,Zhan J,Yin Y,Liu C,Zhang C,Lu G,Li W,Liu J,Chen ZJ,Liu H
PA5-27195 was used in Immunocytochemistry to demonstrate the function of ZCWPW1 that acts as part of the selection system for epigenetics-based recombination hotspots in mammals.
Wed May 06 00:00:00 EDT 2020
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Nature communications
Zhang J,Gurusaran M,Fujiwara Y,Zhang K,Echbarthi M,Vorontsov E,Guo R,Pendlebury DF,Alam I,Livera G,Emmanuelle M,Wang PJ,Nandakumar J,Davies OR,Shibuya H
PA5-27195 was used in Immunocytochemistry-immunoflourescence to identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association.
Tue Apr 28 00:00:00 EDT 2020
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Nature communications
Zhang J,Gurusaran M,Fujiwara Y,Zhang K,Echbarthi M,Vorontsov E,Guo R,Pendlebury DF,Alam I,Livera G,Emmanuelle M,Wang PJ,Nandakumar J,Davies OR,Shibuya H
PA5-27195 was used in Immunocytochemistry-immunoflourescence to identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association.
Tue Apr 28 00:00:00 EDT 2020
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Nature communications
Zhang J,Gurusaran M,Fujiwara Y,Zhang K,Echbarthi M,Vorontsov E,Guo R,Pendlebury DF,Alam I,Livera G,Emmanuelle M,Wang PJ,Nandakumar J,Davies OR,Shibuya H
PA5-27195 was used in Immunocytochemistry-immunoflourescence to identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association.
Tue Apr 28 00:00:00 EDT 2020
SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
Nucleic acids research
Liu H,Huang T,Li M,Li M,Zhang C,Jiang J,Yu X,Yin Y,Zhang F,Lu G,Luo MC,Zhang LR,Li J,Liu K,Chen ZJ
PA5-27195 was used in Immunocytochemistry-immunoflourescence to identify a novel protein, synaptonemal complex reinforcing element as a key molecule in maintaining the integrity of synaptonemal complex during meiosis prophase 1 in mice.
Thu Jun 20 00:00:00 EDT 2019
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Nature communications
Zhang J,Fujiwara Y,Yamamoto S,Shibuya H
PA5-27195 was used in Western Blotting to study the role of BRCA2 in the repair mechanism of double stranded breaks.
Wed Feb 13 00:00:00 EST 2019
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Nature communications
Zhang J,Fujiwara Y,Yamamoto S,Shibuya H
PA5-27195 was used in Western Blotting to study the role of BRCA2 in the repair mechanism of double stranded breaks.
Wed Feb 13 00:00:00 EST 2019
Drugging DNA repair to target T-ALL cells.
Leukemia & lymphoma
Dasgupta Y,Golovine K,Nieborowska-Skorska M,Luo L,Matlawska-Wasowska K,Mullighan CG,Skorski T
PA5-27195 was used in Immunocytochemistry to hypothesize that targeting PARP1 and RAD52 will induce synthetic lethality in TALLs/ETP-ALLs displaying 'BRCAness' and spare normal cells.
Sun Jul 01 00:00:00 EDT 2018
Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.
Nucleic acids research
Manjón E,Edreira T,Muñoz S,Sánchez Y
PA5-27195 was used in Immunohistochemistry-immunofluorescence to explore the sensitivity of a deletion mutation in the Rho1p exchange factor Rgf1p to the DNA break/inducing antibiotic phleomycin.
Fri May 19 00:00:00 EDT 2017
DNA metabolism protein
