Immunogen sequence: MRGKTFRFEMQ RDLVSFPLSP AVRVKLVSAG FQTAEELLEV KPSELSKEVG ISKAEALETL QIIRRECLTN KPRYAGTSES HKKCTALELL EQEHTQGFII TFCSALDDIL GGGVPLMKTT EICGAPGVG
Highest antigen sequence identity to the following orthologs - mouse 79%, rat 82%.
ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
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Protein Aliases: DNA repair protein RAD51 homolog 3; MGC104277; R51H3; RAD51 homolog C; RAD51-like protein 2; yeast RAD51 homolog 3
Gene Aliases: BROVCA3; FANCO; R51H3; RAD51C; RAD51L2
UniProt ID: (Human) O43502
Entrez Gene ID: (Human) 5889