This target displays homology in the following species: Horse: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
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Protein Aliases: E3 ubiquitin-protein ligase RAG1; Endonuclease RAG1; RAG-1; recombinase activating gene 1; recombination activating protein 1; recombination activation protein 1; recombination-activating gene 1; RING-type E3 ubiquitin transferase RAG1; V(D)J recombination-activating protein 1
Gene Aliases: Rag-1; RAG1