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Invitrogen
RAMP1 Polyclonal Antibody
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Product Details
PA5-110265
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
65 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CPISGRAVRD PPGS
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1; MGC38240; RAMP1; receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; Receptor activity-modifying protein 1; type I transmembrane protein
Gene Aliases: 9130218E19Rik; RAMP1
UniProt ID: (Human) O60894, (Rat) Q9JJ74, (Mouse) Q9WTJ5
Entrez Gene ID: (Human) 10267, (Rat) 58965, (Mouse) 51801
calcitonin gene-related peptide receptor activity
protein binding
coreceptor activity
amylin receptor activity
calcitonin gene-related peptide binding
G-protein coupled receptor binding
receptor activity
calcitonin receptor activity
protein transporter activity
calcitonin receptor binding
protein heterodimerization activity
transmembrane signal receptor
angiogenesis
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
protein transport
receptor internalization
cellular response to hormone stimulus
positive regulation of protein glycosylation
protein localization to plasma membrane
amylin receptor signaling pathway
amylin receptor 1 signaling pathway
calcitonin gene-related peptide receptor signaling pathway
signal transduction
positive regulation of cAMP biosynthetic process
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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