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RAMP2 Polyclonal Antibody
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Product Details
BS-11971R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RAMP2, amino acids 81-175.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; RAMP2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2 isoform; Receptor activity-modifying protein 2; RP23-281C18.6; type I transmembrane protein
Gene Aliases: RAMP2
UniProt ID: (Human) O60895, (Mouse) Q9WUP0, (Rat) Q9JHJ1
Entrez Gene ID: (Human) 10266, (Mouse) 54409, (Rat) 58966
angiogenesis
vasculogenesis
sprouting angiogenesis
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
regulation of blood pressure
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
receptor internalization
cellular response to hormone stimulus
adherens junction assembly
cellular response to vascular endothelial growth factor stimulus
negative regulation of vascular permeability
positive regulation of angiogenesis
bicellular tight junction assembly
basement membrane assembly
protein localization to plasma membrane
vascular smooth muscle cell development
amylin receptor 2 signaling pathway
adrenomedullin receptor signaling pathway
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
cAMP biosynthetic process
transport
signal transduction
positive regulation of cAMP biosynthetic process
response to hypoxia
female pregnancy
response to estradiol
response to progesterone
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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