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Product Details
11861-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
RAMP3 Fusion Protein Ag2438 (1-148 aa encoded by BC022304) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.17 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: METGALRRP QLLPLLLLLC GGCPRAGGCN ETGMLERLPL CGKAFADMMG KVDVWKWCNL SEFIVYYESF TNCTEMEANV VGCYWPNPLA QGFITGIHRQ FFSNCTVDRV HLEDPPDEVL IPLIVIPVVL TVAMAGLVVW RSKRTDTLL (1-148 aa encoded by BC022304 )
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3; receptor activity modifying protein 3; Receptor activity-modifying protein 3; receptor-activity-modifying protein 3
Gene Aliases: AI850306; RAMP3
UniProt ID: (Human) O60896, (Mouse) Q9WUP1
Entrez Gene ID: (Human) 10268, (Mouse) 56089
Molecular Function:
transmembrane signal receptor
positive regulation of receptor recycling
calcium ion transport
intracellular protein transport
regulation of G-protein coupled receptor protein signaling pathway
protein transport
receptor internalization
negative regulation of transcription, DNA-templated
cellular response to estradiol stimulus
protein localization to plasma membrane
G-protein coupled receptor signaling pathway involved in heart process
positive regulation of establishment of protein localization to plasma membrane
transport
signal transduction
G-protein coupled receptor signaling pathway
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