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Invitrogen
RAN Polyclonal Antibody
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FIGURE: 1 / 4
RAN Antibody (PA5-17652) in ICC/IF
Immunofluorescence analysis of RAN was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with RAN Polyclonal Antibody (Product # PA5-17652) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790) at a dilutio... View More
Product Details
PA5-17652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Fruit fly,
Hamster,
Human,
Mouse,
Non-human primate,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Two synthetic peptides corresponding to amino acids surrounding Arg29 and Asn143 of human Ran
Conjugate
Form
Liquid
Concentration
20 µg/mL
Amount
2 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other small GTPases of the Ras family.
Target Information
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor-associated protein 24; ARA25; CG1404-PA; CG1404-PB; CG1404-PC; CG1404-PD; G protein; RAN/TC4; ARA24; GM14354p; GTP-binding nuclear protein Ran; GTPase Ran; guanosine triphosphatase Ran; LD32416p; LD40852p; member RAS oncogene family; OTTHUMP00000166078; OTTHUMP00000166102; RAN; ran GTP-binding protein; Ran GTPase; RAN, member RAS oncogene family; Ran-PA; Ran-PB; Ran-PC; Ran-PD; RanGTPase; ras-like protein; Ras-like protein TC4; Ras-related nuclear protein; unnamed protein product
Gene Aliases: AAF30287; ARA24; CG1404; Dmel\CG1404; Dmel_CG1404; dran; Gsp1; I79_024397; l(1)G0075; OK/SW-cl.81; Q9VZ23; RAN; ran-1; Ran10A; RanGTP; RanTC4; Rasl2-8; TC4; XELAEV_18007741mg; xran
magnesium ion binding
GTPase activity
GTP binding
nucleotide binding
chromatin binding
RNA binding
obsolete small monomeric GTPase activity
nuclear export signal receptor activity
protein binding
hydrolase activity
GDP binding
protein domain specific binding
macromolecular complex binding
cadherin binding
dynein intermediate chain binding
metal ion binding
protein heterodimerization activity
importin-alpha family protein binding
pre-miRNA binding
poly(A) RNA binding
protein complex binding
small GTPase
mitotic sister chromatid segregation
protein import into nucleus
protein export from nucleus
actin cytoskeleton organization
cellular protein complex localization
GTP metabolic process
cell division
snRNA import into nucleus
ribosomal subunit export from nucleus
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
mitotic cell cycle
glycolytic process
DNA metabolic process
nucleocytoplasmic transport
mitotic spindle organization
spermatid development
protein localization
protein transport
viral process
hippocampus development
protein complex localization
pre-miRNA export from nucleus
positive regulation of protein import into nucleus
cellular response to mineralocorticoid stimulus
protein localization to nucleolus
microtubule cytoskeleton organization
mitotic nuclear division
small GTPase mediated signal transduction
metabolic process
positive regulation of protein binding
cellular protein localization
establishment of mitotic spindle orientation
meiotic spindle organization
intracellular protein transport
regulation of mitotic cell cycle
regulation of protein localization
nuclear pore complex assembly
protein import into nucleus, translocation
transport
cell cycle
signal transduction
regulation of protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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