This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA1-31482 detects RanGAP1 from human, mouse samples.
PA1-31482 has been successfully used in Western blot applications.
The PA1-31482 immunogen is: Synthetic peptide: ASEDIAKLAETLAK (Human).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Fug1; KIAA1835; MGC20266; Ran GTPase-activating protein 1; RanGAP1; SD; segregation distorter homolog; segregation distortion
Gene Aliases: BOS_6203; C79654; Fug1; KIAA1835; mKIAA1835; RANGAP; RANGAP1; SD