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Invitrogen
RAP Polyclonal Antibody
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Product Details
PA5-91892
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human LRPAP1 (P30533)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
31 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: K-562, THP-1, HepG2; Cellular Location: Cell surface, Cytoplasm, Endoplasmic reticulum
Immunogen sequence: GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI H
Target Information
The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39 kDa receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); Alpha-2-MRAP; Gp330-binding 45 kDa protein; HBP-44; Heparin-binding protein 44; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein associated protein 1; Low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); RAP; unnamed protein product
Gene Aliases: A2MRAP; A2RAP; AA617339; AI790446; alpha-2-MRAP; AU042172; C77774; HBP44; LRPAP1; MRAP; MYP23; RAP
UniProt ID: (Human) P30533, (Rat) Q99068, (Mouse) P55302
Entrez Gene ID: (Human) 4043, (Rat) 116565, (Mouse) 16976
negative regulation of receptor internalization
signal transduction
negative regulation of very-low-density lipoprotein particle clearance
regulation of receptor-mediated endocytosis
amyloid-beta clearance by transcytosis
extracellular negative regulation of signal transduction
negative regulation of beta-amyloid clearance
positive regulation of beta-amyloid clearance
negative regulation of protein binding
negative regulation of receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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