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Invitrogen
RAP1A Polyclonal Antibody
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Product Details
PA1-29451
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Guinea pig,
Hamster,
Human,
Mouse,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a portion of human Rap1a. Peptide differs from Rap1b by two residues.
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is expected to cross-react with zebrafish and C. elegans based on sequence homology of 100% and 94%, respectively.
PA1-29451 has been successfully used in Western blot applications where a band of 25 kDa is detected. Positive control: rat brain tissue extract.
Target Information
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C21KG; G-22K; GTP-binding protein; GTP-binding protein smg p21A; GTP-binding protein SMG-P21A; RAP1A, member of RAS oncogene family; RAS-related protein 1a; Ras-related protein Krev-1; Ras-related protein Rap-1A; ras-related protein Rap-1A-like protein; small GTP binding protein; unnamed protein product
Gene Aliases: AI848598; C21KG; G-22K; KREV-1; KREV1; rap 1A; RAP-1A; RAP1; RAP1A; SMGP21; XELAEV_18014793mg
UniProt ID: (Human) P62834, (Bovine) P62833, (Mouse) P62835, (Rat) P62836
nucleotide binding
GTPase activity
obsolete small monomeric GTPase activity
guanyl-nucleotide exchange factor activity
protein binding
GTP binding
hydrolase activity
GDP binding
small GTPase binding
macromolecular complex binding
Rap guanyl-nucleotide exchange factor activity
protein transporter activity
Ras GTPase binding
protein complex binding
small GTPase
signal transduction
small GTPase mediated signal transduction
nervous system development
response to carbohydrate
positive regulation of neuron projection development
synaptic vesicle exocytosis
Rap protein signal transduction
negative regulation of collagen biosynthetic process
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of protein kinase activity
positive regulation of glucose import
positive regulation of phagocytosis
positive regulation of Fc receptor mediated stimulatory signaling pathway
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to plasma membrane
response to antineoplastic agent
liver regeneration
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
regulation of cell junction assembly
cellular response to forskolin
cellular response to nerve growth factor stimulus
negative regulation of synaptic vesicle exocytosis
positive regulation of vasculogenesis
protein transport
metabolic process
microvillus assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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